Polysorbate 80 Breaking The Blood Brain Barrier (BBB)
The BBB is part of the ‘neuroimmune system’ (8) and is a semipermeable membrane (9), meaning it only allows certain things to pass, but keeps unwanted or unrequired things out.
The BBB blocks un-needed toxic substances from gaining access into the fluid of the central nervous system (CNS) (10)
The CNS’s functions are vast, it controls memory, speech, thought, movements, sensations and awareness and much more.
If breached with toxic materials, you can see where issues will arise. And that is precisely what polysorbate 80 does. It opens the castle gates, lifts the portcullis and calls off the archers.
It is the Trojan horse bringing unwanted attackers inside the body or more accurately the brain. There is a lot of evidence to show that Polysorbate 80 is used to deliver drugs to the brain.
The problem is it also does the same with food, drink & cosmetics, it drags everything mixed in the product directly to the BBB then into the brain, where they lodges to create havoc.
Here’s an excerpt from a good source www.researchgate.net (11)
“It was reported that nanoparticles with polysorbate 80 (Tween 80, T-80) coating represented tools used for delivering drugs to brain. Nevertheless, disputations were once aroused for some complications.
Aimed to have a better understanding of the specific role of T-80 coating on nanoparticles and simplify the problem, the direct observation of brain targeting combined with in vivo experiments was carried out in this work using the model nanoparticles (MNPs).
The presence of a complex composed by the model loading, T-80 and nanoparticles was found in the preparation of MNPs. The result was further supported by some surface properties of MNPs. Being bound to nanoparticles that were overcoated by T-80 later, was necessary for the loading to be delivered to brain.
Partial coverage was enough for T-80 coating to play a specific role in brain targeting. It seemed that brain targeting of nanoparticles was concerned with the interaction between T-80 coating and brain micro-vessel endothelial cells.
“Therefore, the specific role of T-80 coating on nanoparticles in brain targeting was confirmed”
The BBB & CNS deserve articles of their own.